Current and Future Therapies for Hepatitis C Virus Infection | New England Journal of Medicine
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The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …

Summary Type I Interferons (IFNs) are important cytokines for innate immunity against
viruses and cancer. Sixteen human type I IFN variants signal through the same cell-surface …

Hepatitis C virus (HCV) infection blocks cellular interferon (IFN)‐mediated antiviral signaling
through cleavage of Cardif by HCV‐NS3/4A serine protease. Like NS3/4A, NS4B protein …

Replication of flaviviruses (family Flaviviridae) occurs in specialized virus-induced
membrane structures (IMS). The cellular composition of these IMS varies for different …

Hepatitis C virus (HCV) causes chronic infection in almost 2% of the world9s population. If
untreated, chronic carriers can develop severe liver disease including fibrosis, cirrhosis and …

Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We
identified an amphipathic helix (AH) in the N-terminal region of the viral nonstructural protein …

ABSTRACT Nonstructural protein 4B (NS4B) is a key organizer of hepatitis C virus (HCV)
replication complex formation. It induces a specific membrane rearrangement, designated …

The design, synthesis, and SAR studies of novel inhibitors of HCV NS4B based on the
imidazo [2, 1-b] thiazole scaffold were described. Optimization of potency with respect to …

The hepatitis C virus (HCV) non-structural (NS) 5A protein plays an essential role in the
replication of the viral RNA by the membrane-associated replication complex (RC) …