MicroRNAs: roles in cardiovascular development and disease

S Kalayinia, F Arjmand, M Maleki, M Malakootian… - Cardiovascular …, 2021 - Elsevier
Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …

Crafting a blueprint for MicroRNA in cardiovascular diseases (CVDs)

SU Khan, S Saeed, AN Sheikh, FM Arbi… - Current Problems in …, 2023 - Elsevier
Cardiovascular diseases (CVDs) encompass a range of disorders, from congenital heart
malformation, cardiac valve, peripheral artery, coronary artery, cardiac muscle diseases, and …

Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?

P Willeit, P Skroblin, S Kiechl… - European heart …, 2016 - academic.oup.com
Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the
regulation of gene expression. In this review, we summarize the rapidly evolving knowledge …

Exosomes in cardiovascular diseases: pathological potential of nano-messenger

AS Jadli, A Parasor, KP Gomes, R Shandilya… - Frontiers in …, 2021 - frontiersin.org
Cardiovascular diseases (CVDs) represent a major global health problem, due to their
continued high incidences and mortality. The last few decades have witnessed new …

Mitochondrial noncoding RNA-regulatory network in cardiovascular disease

A Jusic, Y Devaux… - Basic research in …, 2020 - Springer
Mitochondrial function and integrity are vital for the maintenance of cellular homeostasis,
particularly in high-energy demanding cells. Cardiomyocytes have a large number of …

miR-30c and miR-181a synergistically modulate p53–p21 pathway in diabetes induced cardiac hypertrophy

SK Raut, GB Singh, B Rastogi, UN Saikia… - Molecular and cellular …, 2016 - Springer
Abstract p53–p21 pathway mediates cardiomyocyte hypertrophy and apoptosis and is
upregulated in diabetic cardiomyopathy (DbCM). We investigated role of microRNAs in …

Cardiac‐specific overexpression of miR‐122 induces mitochondria‐dependent cardiomyocyte apoptosis and promotes heart failure by inhibiting Hand2

Y Shi, Z Zhang, Q Yin, C Fu, A Barszczyk… - Journal of cellular …, 2021 - Wiley Online Library
Abstract MicroRNA‐122 (miR‐122) is one of several microRNAs elevated in heart failure
patients. To investigate the potential role and mechanism of miR‐122 in heart failure, we …

Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides

N Ghosh, R Katare - Cardiovascular diabetology, 2018 - Springer
Diabetic cardiomyopathy (DCM) is a chronic complication in individuals with diabetes and is
characterized by ventricular dilation and hypertrophy, diastolic dysfunction, decreased or …

A microRNA's journey to the center of the mitochondria

AM Macgregor-Das, S Das - American Journal of …, 2018 - journals.physiology.org
MicroRNAs (miRNAs) are known as the master regulators of gene expression, and for the
last two decades our knowledge of their functional reach keeps expanding. Recent studies …

Circulating miRNAs as potential biomarkers associated with cardiac remodeling and fibrosis in chagas disease cardiomyopathy

CKV Nonaka, CT Macêdo, BRR Cavalcante… - International journal of …, 2019 - mdpi.com
Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30%
develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years …