Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Life is a non‐equilibrium state of matter maintained at the expense of energy. Nature uses
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …

Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such
as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control …

A key question in understanding microtubule dynamics is how GTP hydrolysis leads to
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …

Microtubules are dynamic tubulin polymers responsible for many cellular processes,
including the capture and segregation of chromosomes during mitosis. In contrast to …

The function of microtubules relies on their ability to switch between phases of growth and
shrinkage. A nucleotide-dependent stabilising cap at microtubule ends is thought to be lost …

Microtubules are dynamic cytoskeletal filaments composed of αβ-tubulin heterodimers.
Historically, the dynamics of single tubulin interactions at the growing microtubule tip have …

Mitochondria are cellular organelles of crucial importance, playing roles in cellular life and
death. In certain cell types, such as neurons, mitochondria must travel long distances so as …

Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These
infrequent transitions, termed" catastrophes", affect numerous cellular processes but the …