Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Post-stroke cognitive impairment occurs frequently in the patients with stroke. The
prevalence of post-stroke cognitive impairment ranges from 20% to 80%, which varies for …

Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Abstract Silent information regulator 1 (SIRT 1), a type of histone deacetylase, is a highly
effective therapeutic target for protection against ischemia reperfusion (IR) injury (IRI) …

The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which
regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of …

Historically, the direct release of pineal melatonin into the capillary bed within the gland has
been accepted as the primary route of secretion. Herein, we propose that the major route of …

Apart from its potent antioxidant property, recent studies have revealed that melatonin
promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice …