Mice are arguably the experimental workhorse of immunological research and mouse
models have paved the way for the discovery of numerous important mechanisms related to …

The first comprehensive single-source reference on the minipig, this accessible manual
provides a resource for research scientists on the potential and use of the minipig as a …

Accurate spatiotemporal expression of immunomodulatory and anticoagulant proteins on
the endothelial cells of transgenic pigs is required for the successful xenotransplantation of …

Background Among other mismatches between human and pig, incompatibilities in the
blood coagulation systems hamper the xenotransplantation of vascularized organs. The …

In this review, we summarize the work published over the last 2 years using genetic
modifications of animals in the field of xenotransplantation. Genetic engineering of the donor …

Thrombomodulin is important for the production of activated protein C (APC), a molecule
with significant regulatory roles in coagulation and inflammation. To address known …

Abstract Myozenin-1 (Myoz1) gene-encoded calsarcin-2 protein was expressed exclusively
in fast-twitch muscles. Peroxisome proliferator-activated receptor γ2 (PPAR-γ2) is a key …

NFкB transcription activation leads to malfunction of endothelial cells, which is the main
reason for pig xenograft rejection. Overexpression of a dominant negative mutant of porcine …

Background The use of a transgenic pig for xenotransplantation and as a cardiovascular
disease model has caught much attention in the past decades. The vascular endothelial cell …

Nucleotide metabolism in endothelium is variable between different species. Recent studies
demonstrated that this variability could contribute coagulation dysfunction, even though …