The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Protein kinase CK2 has received a surge of attention in recent years due to the evidence of
its overexpression in a variety of solid tumors and multiple myelomas as well as its …

Background GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described
neurodegenerative disease caused by (GAA)≥ 250 expansions in the fibroblast growth …

Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth
factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in …

The finely tuned regulation of neuronal firing relies on the integrity of ion channel
macromolecular complexes. Minimal disturbances of these tightly regulated networks can …

Glycogen synthase kinase 3β (GSK3) is a multifaceted serine/threonine (S/T) kinase
expressed in all eukaryotic cells. GSK3β is highly enriched in neurons in the central nervous …

Neurons are highly polarized cells with apparent functional and morphological differences
between dendrites and axon. A critical determinant for the molecular and functional identity …

Posttranslational regulation of cardiac NaV1. 5 channels is critical in modulating channel
expression and function, yet their regulation by phosphorylation of accessory proteins has …

Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of
hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels …

Background Cognitive impairment in humans with Alzheimer's disease (AD) and in animal
models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor …