Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …

In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30
years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for …

Tubulin plays essential roles in vital cellular activities and is the target of a wide range of
proteins and ligands. Here, using a combined computational and crystallographic fragment …

Microtubules (MTs) are polymers assembled from αβ-tubulin heterodimers that display the
hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within …

The microtubule cytoskeleton forms complex macromolecular assemblies with a range of
microtubule-associated proteins (MAPs) that have fundamental roles in cell architecture …

Microtubules are cytoskeletal polymers whose function depends on their property to switch
between states of growth and shrinkage. Growing microtubules are thought to be stabilized …

Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high
eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus …

Ran is a member of the Ras superfamily of proteins, which primarily regulates
nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and …