We have used 16 human x mouse somatic cell hybrids containing a variable number of
human chromosomes to demonstrate that the human (Y-globin gene is on chromosome 16 …

This article focuses on current techniques and possible future developments in chromosome
isolation and sorting, and DNA analysis of sorted chromosomes. The strategy of …

The discovery in the late 1940's that sickle cell anemia is a" molecular disease" of
hemoglobin was the crucial advance that gave birth to the scientific discipline of human …

A history of genetic testing warns that such tests may tell us more than we want to know.
Medical geneticists began mapping the chromosomal infrastructure piece by piece in the …

Normal human metaphase chromosomes isolated from fibroblasts were resolved into 14
peaks based on total Hoechst 33258 fluorescence and sorted with the fluorescence …

DNA from a clone of a mouse-human hybrid that retained a human chromosome consisting
of the major part of chromosome 11 and region q25-26-qter of the X chromosome was …

Abstract A 3.7-kilobase (kb) genomic clone of the human beta-globin gene, including 1.5-kb
upstream and approximately 0.5-kb downstream, was utilized in chromosomal in situ …

The hybridization of 5S and 28S ribosomal RNAs to human fibroblast and leukocyte cells
was used as a model system to quantitate the technique of in situ hybridization for human …

Hybridization of rabbit reticulocyte mRNA to banded mouse chromosomes in situ labeled
several regions, including the globin loci. Whereas the labeling was sufficient to detect …

THERE is disagreement about the site of the human haemoglobin structural genes, mapping
of which has been attempted by in situ hybridisation1–4 and family studies5, 6. After in situ …