The adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway
arose early during evolution of eukaryotic cells, when it appears to have been involved in …

With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most
prevalent liver disease worldwide. A substantial increase in the incidence, mortality, and …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that is almost
universally expressed in eukaryotic cells. While it appears to have evolved in single-celled …

Metabolic syndrome, such as diabetes mellitus, obesity, atherosclerosis, and high blood
pressure (HBP), are closely linked pathophysiologically. However, current monotherapies …

Our previous data indicated that tanshinone IIA (tan IIA) improves learning and memory in a
mouse model of Alzheimer's disease (AD) induced by streptozotocin via restoring …

Because of its high prevalence and poor long-term clinical treatment effect, liver disease is
regarded as a major public health problem around the world. Among them, viral hepatitis …

Non-alcoholic fatty liver disease (NAFLD) is a chronic disorder of lipid and carbohydrate
metabolism and is often associated with endoplasmic reticulum stress, energy homeostasis …

Type 2 diabetes mellitus (T2DM) and heart failure (HF) are diseases characterized by high
morbidity and mortality. They often occur simultaneously and increase the risk of each other …

The proliferation of vascular smooth muscle cells may perform a crucial role in the
pathogenesis of diabetic vascular disease. AMPK additionally exerts several salutary effects …

Endoplasmic reticulum (ER) stress caused by β-amyloid protein (Aβ) may play an important
role in the pathogenesis of Alzheimer disease (AD). Our previous data have indicated that …