Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins,
and other molecules, and has been used in many research fields because of its beneficial …

Over the past decade, theranostic imaging has emerged as a powerful clinical tool in
oncology for identifying patients likely to respond to targeted therapies and for monitoring …

Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …

Bioorthogonal click chemistry—employing antibody-conjugated trans-cyclooctenes (TCO)
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …

Background Aberrant glycosylation patterns play a crucial role in the development of cancer
cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate …

Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA)
reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive …

The advent of bioorthogonal chemistry has led to the development of powerful chemical
tools that enable increasingly ambitious applications. In particular, these tools have made it …

Rationale: Pretargeted radioimmunotherapy (PRIT) based upon bioorthogonal click
chemistry has been investigated for the first time in the context of peritoneal carcinomatosis …

Radiolabeled antibodies have shown promise as tools for both the nuclear imaging and
endoradiotherapy of cancer, but the protracted circulation time of radioimmunoconjugates …