Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

The malaria parasite is the most important member of the Apicomplexa, a large and highly
successful phylum of intracellular parasites. Invasion of host cells allows apicomplexan …

The phylum Apicomplexa comprises important eukaryotic parasites that invade host tissues
and cells using a unique mechanism of gliding motility. Gliding is powered by actomyosin …

The completion of the genome sequence for Plasmodium falciparum, the species
responsible for most malaria human deaths, has the potential to reveal hundreds of new …

Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …

Toxoplasma gondii is an obligate intracellular protozoan parasite which is a significant
human and veterinary pathogen. Other members of the phylum Apicomplexa are also …

The glideosome of apicomplexan parasites is an actin-and myosin-based machine located
at the pellicle, between the plasma membrane (PM) and inner membrane complex (IMC) …

Intracellular parasites use various strategies to invade cells and to subvert cellular signaling
pathways and, thus, to gain a foothold against host defenses. Efficient cell entry, ability to …

Apicomplexan parasites constitute one of the most significant groups of pathogens infecting
humans and animals. The liver stage sporozoites of Plasmodium spp. and tachyzoites of …

Introduction: PPIs are involved in every disease and specific modulation of these PPIs with
small molecules would significantly improve our prospects of developing therapeutic agents …