Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Cholesterol and its relatives possessing the 1, 2-cyclopentanoperhydrophenanthrene ring
system (Figure 1) form the sterolome, which comprises a chemical library of more than 1000 …

Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

Background. Oral triazole therapy is well established for the treatment of invasive (IPA),
allergic (ABPA), and chronic pulmonary (CPA) aspergillosis, and is often long-term. Triazole …

The burden of human disease associated with fungal infections is generally
underappreciated, with estimates indicating as many as 150 million persons infected …

The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …

Triazole resistance is an increasing concern in the opportunistic mold Aspergillus fumigatus.
Resistance can develop through exposure to azole compounds during azole therapy or in …

The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …

Infections by fungal pathogens such as Candida albicans and Aspergillus fumigatus and
their resistance to triazole drugs are major concerns. Fungal lanosterol 14α-demethylase …

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and
treatments for superficial and disseminated fungal infections, but cure rates are not optimal …