[HTML][HTML] Shooting at a moving target—effectiveness and emerging challenges for sars-cov-2 vaccine development
F Günl, A Mecate-Zambrano, S Rehländer, S Hinse… - Vaccines, 2021 - mdpi.com
Since late 2019 the newly emerged pandemic SARS-CoV-2, the causative agent of COVID-
19, has hit the world with recurring waves of infections necessitating the global …
19, has hit the world with recurring waves of infections necessitating the global …
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …
[PDF][PDF] Structural basis for accommodation of emerging B. 1.351 and B. 1.1. 7 variants by two potent SARS-CoV-2 neutralizing antibodies
Summary Emerging SARS-CoV-2 strains, B. 1.1. 7 and B. 1.351, from the UK and South
Africa, respectively, show decreased neutralization by monoclonal antibodies and …
Africa, respectively, show decreased neutralization by monoclonal antibodies and …
[HTML][HTML] Modeling SARS-CoV-2 spike/ACE2 protein–protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally …
V Tragni, F Preziusi, L Laera, A Onofrio, I Mercurio… - EPMA Journal, 2022 - Springer
Aims The rapid spread of new SARS-CoV-2 variants has highlighted the crucial role played
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …
E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody
S Chakraborty - International immunopharmacology, 2022 - Elsevier
Abstract SARS-CoV2 mutants B. 1.1. 7, B. 1.351, and P. 1 contain a key mutation N501Y. B.
1.135 and P. 1 lineages have another mutation, E484K. Here, we decode the effect of these …
1.135 and P. 1 lineages have another mutation, E484K. Here, we decode the effect of these …
[HTML][HTML] Diminishing immune responses against variants of concern in dialysis patients 4 months after SARS-CoV-2 mRNA vaccination
A Dulovic, M Strengert, GM Ramos… - Emerging Infectious …, 2022 - ncbi.nlm.nih.gov
Patients undergoing chronic hemodialysis were among the first to receive severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased …
respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased …
[HTML][HTML] Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections
Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination
is crucial to develop strategies for longer term immunity, especially against emerging viral …
is crucial to develop strategies for longer term immunity, especially against emerging viral …
[HTML][HTML] Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine
G Deliyannis, NA Gherardin, CY Wong, SL Grimley… - …, 2023 - thelancet.com
Summary Background The SARS-CoV-2 global pandemic has fuelled the generation of
vaccines at an unprecedented pace and scale. However, many challenges remain …
vaccines at an unprecedented pace and scale. However, many challenges remain …
RAGE is a receptor for SARS-CoV-2 N protein and mediates N protein–induced acute lung injury
J Xia, J Wang, L Ying, R Huang, K Zhang… - American Journal of …, 2023 - atsjournals.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-
protein) increases early in body fluids during infection and has recently been identified as a …
protein) increases early in body fluids during infection and has recently been identified as a …
[HTML][HTML] Nasal mucosal IgA levels against SARS-CoV-2 and seasonal coronaviruses are low in children but boosted by reinfection
Repeated coronavirus infections in childhood drive progressive maturation of systemic
immune responses into adulthood. Analyses of immune responses in children have focused …
immune responses into adulthood. Analyses of immune responses in children have focused …