A noticeable increase in molecular complexity of drug targets has created an unmet need in
the therapeutic agents that are larger than traditional small molecules. Macrocycles, which …

Antimicrobial peptides (AMPs) are an important component of the natural defences of most
living organisms against invading pathogens. These are relatively small (< 10kDa), cationic …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

Chemical shifts are the universal language of nuclear magnetic resonance (NMR). They
communicate in a simple way detailed molecular information that almost every chemist can …

Deep learning networks offer considerable opportunities for accurate structure prediction
and design of biomolecules. While cyclic peptides have gained significant traction as a …

We have investigated the role of amphipathicity in a homologous series of head-to-tail cyclic
antimicrobial peptides in efforts to delineate features resulting in high antimicrobial activity …

The C-terminal thioesterase (TE) domains from nonribosomal peptide synthetases (NRPSs)
catalyze the final step in the biosynthesis of diverse biologically active molecules. In many …

MicroRNAs (miRNAs) help orchestrate cellular growth and survival through post-
transcriptional mechanisms. The dysregulation of miRNA biogenesis can lead to cellular …

The cyclic β‐sheet structure possessed by the 10‐residue antibiotic peptide gramicidin S
was taken as the structural framework for the de novo design of biologically active peptides …

Overuse of antibiotics is one of the important factors that contribute to developing
antimicrobial resistance. Many studies have been conducted to find out promising solutions …