A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Elastin, arterial mechanics, and cardiovascular disease

AJ Cocciolone, JZ Hawes… - American Journal …, 2018 - journals.physiology.org
Large, elastic arteries are composed of cells and a specialized extracellular matrix that
provides reversible elasticity and strength. Elastin is the matrix protein responsible for this …

25th anniversary article: Rational design and applications of hydrogels in regenerative medicine

N Annabi, A Tamayol, JA Uquillas, M Akbari… - Advanced …, 2014 - Wiley Online Library
Hydrogels are hydrophilic polymer‐based materials with high water content and physical
characteristics that resemble the native extracellular matrix. Because of their remarkable …

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

BB Holmes, SL DeVos, N Kfoury, M Li… - Proceedings of the …, 2013 - National Acad Sciences
Recent experimental evidence suggests that transcellular propagation of fibrillar protein
aggregates drives the progression of neurodegenerative diseases in a prion-like manner …

Tropoelastin and elastin assembly

J Ozsvar, C Yang, SA Cain, C Baldock… - … in bioengineering and …, 2021 - frontiersin.org
Elastic fibers are an important component of the extracellular matrix, providing stretch,
resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the …

[HTML][HTML] Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective

LD Muiznieks, FW Keeley - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
The extracellular matrix is an integral and dynamic component of all tissues.
Macromolecular compositions and structural architectures of the matrix are tissue-specific …

New insights into elastic fiber assembly

JE Wagenseil, RP Mecham - Birth Defects Research Part C …, 2007 - Wiley Online Library
Elastic fibers provide recoil to tissues that undergo repeated stretch, such as the large
arteries and lung. These large extracellular matrix (ECM) structures contain numerous …

Elastic fibers: Formation, function, and fate during aging and disease

CEH Schmelzer, L Duca - The FEBS Journal, 2022 - Wiley Online Library
Elastic fibers are extracellular components of higher vertebrates and confer elasticity and
resilience to numerous tissues and organs such as large blood vessels, lungs, and skin …

Elastic fibres in health and disease

AK Baldwin, A Simpson, R Steer, SA Cain… - Expert reviews in …, 2013 - cambridge.org
Elastic fibres are insoluble components of the extracellular matrix of dynamic connective
tissues such as skin, arteries, lungs and ligaments. They are laid down during development …

Coacervation of tropoelastin

GC Yeo, FW Keeley, AS Weiss - Advances in colloid and interface science, 2011 - Elsevier
The coacervation of tropoelastin represents the first major stage of elastic fiber assembly.
The process has been modeled in vitro by numerous studies, initially with mixtures of …