In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been
developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) …

I. Structure and identification of mycolic acids 143 A. Generalized structures and properties
of mycolic acids 143 1. An historical perspective on mycolic acid structure 143 2. General …

T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on
tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands …

Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that
are recognized by a subset of γδ T cells expressing the variable region Vδ1. This functional …

T cells with variable region Vδ1 γδ T cell receptors (TCRs) are distributed throughout the
human intestinal epithelium and may function as sentinels that respond to self antigens. The …

T LYMPHOCYTES express either αβ or γδ T-cell receptor heterodimers1, 2. Most αβ T cells
recognize antigenic peptides bound to major histocompatibility complex molecules but the …

MAJOR histocompatibility complex (MHC) class I and class II molecules bind immunogenic
peptides and present them to lymphocytes bearing the αβ T-cell antigen receptor (TCR) 1–4 …

To determine whether T cells, like B cells, can become clonally expanded in normal
individuals as a function of age, we compared the T cell V beta repertoire of cord blood to …

Human Vγ2Vδ2+ T cells recognize mycobacterial non-peptide antigens, such as isopentenyl
pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR …

It has long been the paradigm that T cells recognize peptide antigens presented by major
histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be …