Advances in autism genetics: on the threshold of a new neurobiology

BS Abrahams, DH Geschwind - Nature reviews genetics, 2008 - nature.com
Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …

GABAergic system dysfunction in autism spectrum disorders

H Zhao, X Mao, C Zhu, X Zou, F Peng… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases
characterized by two hallmark symptoms, social communication deficits and repetitive …

The number of parvalbumin-expressing interneurons is decreased in the prefrontal cortex in autism

E Hashemi, J Ariza, H Rogers, SC Noctor… - Cerebral …, 2017 - academic.oup.com
The cognitive phenotype of autism has been correlated with an altered balance of excitation
to inhibition in the cerebral cortex, which could result from a change in the number, function …

[HTML][HTML] Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders

S Camuso, P La Rosa, MT Fiorenza, S Canterini - Neurobiology of disease, 2022 - Elsevier
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

H Won, W Mah, E Kim - Frontiers in molecular neuroscience, 2013 - frontiersin.org
Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by
impairments in social interaction and communication and restricted and repetitive …

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk

S Kumar, K Reynolds, Y Ji, R Gu, S Rai… - Journal of …, 2019 - Springer
Background The development of an autistic brain is a highly complex process as evident
from the involvement of various genetic and non-genetic factors in the etiology of the autism …

Genetics of autistic disorders: review and clinical implications

CM Freitag, W Staal, SM Klauck, E Duketis… - European child & …, 2010 - Springer
Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In
this literature review, we will present an overview on molecular genetic studies in AD and …

New roles for the cerebellum in health and disease

SL Reeber, TS Otis, RV Sillitoe - Frontiers in systems neuroscience, 2013 - frontiersin.org
The cerebellum has a well-established role in maintaining motor coordination and studies of
cerebellar learning suggest that it does this by recognizing neural patterns, which it uses to …

[HTML][HTML] Genetics of autism spectrum disorder: current status and possible clinical applications

H Yoo - Experimental neurobiology, 2015 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is one of the most complex behavioral disorders with a
strong genetic influence. The objectives of this article are to review the current status of …

Social approach in genetically engineered mouse lines relevant to autism

SS Moy, JJ Nadler, NB Young… - Genes, Brain and …, 2009 - Wiley Online Library
Profound impairment in social interaction is a core symptom of autism, a severe
neurodevelopmental disorder. Deficits can include a lack of interest in social contact and low …