Biotechnology increasingly delivers highly promising protein-based biopharmaceutical
candidates to the drug development funnel. For successful biopharmaceutical drug …

Dietary supplements are legally considered foods despite frequently including medicinal
plants as ingredients. Currently, the consumption of herbal dietary supplements, also known …

Hydroxychloroquine (HCQ) has been shown to disrupt autophagy and sensitize cancer cells
to radiation and chemotherapeutic agents. However, the optimal delivery method, dose, and …

Pharmaceutical application of therapeutic proteins has been continuously expanded for the
treatment of various diseases. Efficient and reliable bioanalytical methods are essential to …

Benefits of miniaturized chromatography with various detection modes, such as increased
sensitivity, chromatographic efficiency, and speed, were recognized nearly 50 years ago …

Bioanalytical LC–MS for protein quantification is traditionally based on enzymatic digestion
of the target protein followed by absolute quantification of a specific signature peptide …

During the last years, chemistry was involved in the worldwide effort toward environmental
problems leading to the birth of green chemistry. In this context, green analytical tools were …

Lipid composition and lipid degradation are critical to the stability of liposomal formulations
which can impact the safety and efficacy of the drug. Herein we developed and validated an …

In a book on the analysis of biomolecular interactions by mass spectrometry (MS), a general
introduction of MS technology should not miss. This tutorial chapter does not provide a …

A rapid, sensitive and specific method using liquid chromatography coupled to tandem mass
spectrometry was developed for the simultaneous quantification of hydroxychloroquine …