One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

It is over 50 years since the discovery of microtubules, and they have become one of the
most important drug targets for anti-cancer therapies. Microtubules are predominantly …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural
molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its …

A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …

Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular
functions throughout all phases of the cell cycle. Altered tubulin isotype composition of …

Mesenchymal stem cells (MSCs), as an undifferentiated group of adult multipotent cells,
have remarkable antitumor features that bring them up as a novel choice to treat cancers …

Drugs that are already clinically approved or experimentally tested for conditions other than
cancer, but are found to possess previously unrecognized cytotoxicity towards malignant …