[HTML][HTML] Shared and distinct functions of type I and type III interferons
Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …
including induction by viral infection, activation of shared signaling pathways, and …
[HTML][HTML] Interferon-λ: immune functions at barrier surfaces and beyond
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
[HTML][HTML] Guarding the frontiers: the biology of type III interferons
A Wack, E Terczyńska-Dyla, R Hartmann - Nature immunology, 2015 - nature.com
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
[HTML][HTML] The genomics of human local adaptation
Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …
pressures, leading to multiple genetic adaptations to local environmental conditions. These …
[HTML][HTML] Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection
K Murata, M Asano, A Matsumoto, M Sugiyama… - Gut, 2018 - gut.bmj.com
Objective The clinical significance of polymorphisms in the interleukin-28B gene encoding
interferon (IFN)-λ3, which has antiviral effects, is known in chronic HCV but not in HBV …
interferon (IFN)-λ3, which has antiviral effects, is known in chronic HCV but not in HBV …
Human genetic determinants of viral diseases
AD Kenney, JA Dowdle, L Bozzacco… - Annual review of …, 2017 - annualreviews.org
Much progress has been made in the identification of specific human gene variants that
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …
No love lost between viruses and interferons
V Fensterl, S Chattopadhyay… - Annual review of virology, 2015 - annualreviews.org
The interferon system protects mammals against virus infections. There are several types of
interferons, which are characterized by their ability to inhibit virus replication and resultant …
interferons, which are characterized by their ability to inhibit virus replication and resultant …
[HTML][HTML] Human local adaptation of the TRPM8 cold receptor along a latitudinal cline
Ambient temperature is a critical environmental factor for all living organisms. It was likely an
important selective force as modern humans recently colonized temperate and cold …
important selective force as modern humans recently colonized temperate and cold …
Signatures of long-term balancing selection in human genomes
Balancing selection maintains advantageous diversity in populations through various
mechanisms. Although extensively explored from a theoretical perspective, an empirical …
mechanisms. Although extensively explored from a theoretical perspective, an empirical …
Genome-wide significant risk associations for mucinous ovarian carcinoma
Australian Ovarian Cancer Study Group, H Baker… - Nature …, 2015 - nature.com
Genome-wide association studies have identified several risk associations for ovarian
carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC …
carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC …