Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

For organisms to coordinate their growth and development with nutrient availability, they
must be able to sense nutrient levels in their environment. Here, we review select nutrient …

Ammonia is a ubiquitous by-product of cellular metabolism; however, the biological
consequences of ammonia production are not fully understood, especially in cancer. We …

Yeast ataxin-2, also known as Pbp1, senses the activity state of mitochondria in order to
regulate TORC1. A domain of Pbp1 required to adapt cells to mitochondrial activity is of low …

Yeast ataxin-2, also known as Pbp1 (polyA binding protein-binding protein 1), is an
intrinsically disordered protein implicated in stress granule formation, RNA biology, and …

Rag GTPases assemble into heterodimeric complexes consisting of RagA or RagB and
RagC or RagD in higher eukaryotes, or Gtr1 and Gtr2 in yeast, to relay amino acid signals …

Advancements in metabolomic and genomic research tools are revealing new insights into
how metabolic networks can influence skeletal muscle fiber composition. In this mini-review …

Cells constantly adapt to various environmental changes and stresses. The way in which
nutrient and stress levels in a cell feed back to control metabolism and growth are …

The yeast Saccharomyces cerevisiae has played a vital role in the understanding of the
molecular basis of aging and the relationship of aging process with oxidative stress (non …

The conserved GATOR1 complex consisting of NPRL2-NPRL3-DEPDC5 inhibits
mammalian target of rapamycin complex 1 (mTORC1) in response to amino acid …