Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

Guided bone regeneration (GBR) has become a clinically standard modality for the
treatment of localized jawbone defects. Barrier membranes play an important role in this …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …

Abstract Globally, more than 1.5 million patients undergo bone graft surgeries annually, and
the development of biomaterial scaffolds that mimic natural bone for bone grafting remains a …

Bone has a remarkable potential for self-healing and repair, yet several injury types are non-
healing even after surgical or non-surgical treatment. Regenerative therapies that induce …

Large bone defects are usually managed by replacing lost bone with non-biological
prostheses or with bone grafts that come from the patient or a donor. Bone tissue …

After thirty years of intensive research shaping and optimizing the technology, the approval
of the first mRNA-based formulation by the EMA and FDA in order to stop the COVID-19 …

The recent progress in harnessing the efficient and precise method of DNA editing provided
by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy …

Highlights•mRNA therapeutics could represent the next generation drug for tissue
restoration in regenerative medicine.•Non-immunogenic mRNA can be generated by the …