Overweight and obesity are a worldwide public health problem. Obesity prevalence has
increased considerably, which indicates the need for more studies to better understand …

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …

Background & Aims Fatty liver disease, including non-alcoholic fatty liver (NAFLD) and
steatohepatitis (NASH), has been associated with increased intestinal barrier permeability …

Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant
on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in …

Obesity currently represents a major societal and health challenge worldwide. Its prevalence
has reached epidemic proportions and trends continue to rise, reflecting the need for more …

Beyond their role as emulsifiers of lipophilic compounds, bile acids (BAs) are signaling
endocrine molecules that show differential affinity and specificity for a variety of canonical …

Objective Conjugated bile acids are metabolised by upper small intestinal microbiota, and
serum levels of taurine-conjugated bile acids are elevated and correlated with insulin …

Abstract Purpose of Review We review current evidence regarding changes in bile acid (BA)
metabolism, transport, and signaling after bariatric surgery and how these might bolster fat …

Obesity is a chronic disease characterized by abnormal or excessive fat accumulation that
could impact an individual's health; moreover, the World Health Organization (WHO) has …

Obeticholic acid (OCA) is a farnesoid-X-receptor (FXR) ligand, shown effective in reducing
steatosis and fibrosis in NASH patients. However, OCA causes major side effects including …