The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

Genetic perturbations of cortical development can lead to neurodevelopmental disease,
including autism spectrum disorder (ASD). To identify genomic regions crucial to …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

Cell-to-cell variation is a universal feature of life that affects a wide range of biological
phenomena, from developmental plasticity, to tumour heterogeneity. Although recent …

Cultured stem cells have become a standard platform not only for regenerative medicine
and developmental biology but also for biophysical studies. Yet, the characterization of …

Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilize
during adulthood, ensuring lifelong hippocampal neurogenesis. We show that this …

Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms,
allergens, and infectious agents, and play critical roles in resistance and tolerance …

Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …