Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell
signal transduction, which catalyzes the transfer of ATP-γ-phosphate to the tyrosine residues …

Cancer is considered as one of the main causes of human deaths globally. Despite the
recent progresses in therapeutic modalities, there is still a high rate of mortality among …

Abstract Background Circular RNAs (circRNAs) have received increasing attention in human
tumor research. However, there are still a large number of unknown circRNAs that need to …

Troublesome gelation occurring during the dissolution of special co-amorphous (COAM)
systems poses a limitation on their further applications. Metal-Organic Frameworks (MOFs) …

The aim of the present study was to gain insight into the molecular mechanism of gefitinib
resistance in non-small cell lung cancer (NSCLC), and demonstrate whether long …

Interleukin-33 (IL-33) belongs to the interleukin-1 (IL-1) family, and its structure is similar to
IL-18. When cells are damaged or undergo necrosis, mature form of IL-33 is secreted as a …

The present study was aimed to develop and optimize nanoliposomes of gefitinib for
effective tumor targeting. Central composite design was used to study the effect of …

Gefitinib has shown promising efficacy in the treatment of patients with locally advanced or
metastatic EGFR-mutated non-small cell lung cancer (NSCLC). Molecular biomarkers for …

Background. Prior research has identified ANGPTL4 as a key player in the control of the
body's lipid and glucose metabolism and a contributor to the onset of numerous …

Purpose Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor
that has been authorized for the treatment of non-small lung cancer; however, its …