Tolerance and resistance of microbial biofilms

O Ciofu, C Moser, PØ Jensen, N Høiby - Nature Reviews Microbiology, 2022 - nature.com
Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Horizontal gene transfer of antibiotic resistance genes in biofilms

C Michaelis, E Grohmann - Antibiotics, 2023 - mdpi.com
Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix
which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it …

Examining horizontal gene transfer in microbial communities

IL Brito - Nature Reviews Microbiology, 2021 - nature.com
Bacteria acquire novel DNA through horizontal gene transfer (HGT), a process that enables
an organism to rapidly adapt to changing environmental conditions, provides a competitive …

Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level

C Virolle, K Goldlust, S Djermoun, S Bigot, C Lesterlin - Genes, 2020 - mdpi.com
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …

Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Bacterial biofilms and their implications in pathogenesis and food safety

X Bai, CH Nakatsu, AK Bhunia - Foods, 2021 - mdpi.com
Biofilm formation is an integral part of the microbial life cycle in nature. In food processing
environments, bacterial transmissions occur primarily through raw or undercooked foods …

Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations

M Haudiquet, JM de Sousa… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …

Biofilms: architecture, resistance, quorum sensing and control mechanisms

P Saxena, Y Joshi, K Rawat, R Bisht - Indian journal of microbiology, 2019 - Springer
Biofilm is a mode of living employed by many pathogenic and environmental microbes to
proliferate as multicellular aggregates on inert inanimate or biological substrates. Several …

Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes

B Grodner, H Shi, O Farchione, AC Vill, I Ntekas… - Nature …, 2024 - nature.com
The exchange of mobile genetic elements (MGEs) facilitates the spread of functional traits
including antimicrobial resistance within bacterial communities. Tools to spatially map MGEs …

Plasmid persistence: costs, benefits, and the plasmid paradox

AC Carroll, A Wong - Canadian journal of microbiology, 2018 - cdnsciencepub.com
Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as
well as in other domains of life. Nonetheless, the evolutionary processes underlying the …