J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

X Hu, C Zhu, F Sun, Z Chen, J Zou, X Chen… - Advanced …, 2024 - Wiley Online Library
Molecular fluorophores emitting in the second near‐infrared (NIR‐II, 1000–1700 nm)
window with strong optical harvesting and high quantum yields hold great potential for in …

Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine

S Pan, A Ding, Y Li, Y Sun, Y Zhan, Z Ye… - Chemical Society …, 2023 - pubs.rsc.org
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Near-infrared II fluorescence imaging

EL Schmidt, Z Ou, E Ximendes, H Cui… - Nature Reviews …, 2024 - nature.com
Fluorescence imaging in the second near-infrared (NIR-II) window enables deep-tissue
imaging with high resolution and improved contrast by taking advantage of the reduced light …

Advanced techniques for detecting protein misfolding and aggregation in cellular environments

Y Bai, S Zhang, H Dong, Y Liu, C Liu… - Chemical Reviews, 2023 - ACS Publications
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Discovery of high-affinity amyloid ligands using a ligand-based virtual screening pipeline

TS Chisholm, M Mackey, CA Hunter - Journal of the American …, 2023 - ACS Publications
Fibrillar protein aggregates are characteristic of neurodegenerative diseases but represent
difficult targets for ligand design, because limited structural information about the binding …

[HTML][HTML] A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Emerging nanotechnology for Alzheimer's disease: From detection to treatment

N Song, S Sun, K Chen, Y Wang, H Wang… - Journal of Controlled …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), one of the most common chronic neurodegenerative
diseases, is characterized by memory impairment, synaptic dysfunction, and character …

Application of biomarker-derived fluorescent probes for the detection of Alzheimer's disease

H Ding, Z Li, K Luo, Q Gong, X Tian - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

NIR‐II cyanine@ albumin fluorophore for deep tissue imaging and imaging‐guided surgery

Y Zhang, Y Jia, S Zhu - SmartMat, 2023 - Wiley Online Library
Abstract The near‐infrared (NIR)‐II bioimaging technique is highly important for both
diagnosing and treating life‐threatening diseases due to its exceptional imaging …

Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease

H Gao, J Chen, Y Huang, R Zhao - Talanta, 2024 - Elsevier
Misfolding and aggregation of amyloid-β (Aβ) peptides are key hallmarks of Alzheimer's
disease (AD). With accumulating evidence suggesting that different Aβ species have varied …