Advances in research on pharmacotherapy of sarcopenia

Y Feike, L Zhijie, C Wei - Aging Medicine, 2021 - Wiley Online Library
Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal
muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction …

Current pharmacotherapies for sarcopenia

JP Hardee, GS Lynch - Expert Opinion on Pharmacotherapy, 2019 - Taylor & Francis
Introduction: Sarcopenia, the age-related loss of skeletal muscle mass and function, is a
global health problem that contributes to the development of physical disability, morbidity …

Resveratrol and exercise combined to treat functional limitations in late life: a pilot randomized controlled trial

SA Harper, JR Bassler, S Peramsetty, Y Yang… - Experimental …, 2021 - Elsevier
Purpose To evaluate the safety and feasibility of combining exercise (EX) and resveratrol to
treat older adults with physical function limitations. Methods Three-arm, two-site pilot …

Azilsartan ameliorates skeletal muscle wasting in high fat diet (HFD)-induced sarcopenic obesity in rats via activating Akt signalling pathway

P Prajapati, A Kumar, J Singh, SA Saraf… - Archives of Gerontology …, 2023 - Elsevier
An association between the loss of skeletal muscle mass and obesity in the geriatric
population has been identified as a disease known as sarcopenic obesity. Therefore …

Angiotensin‐converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta‐analysis

Y Hu, L Liang, S Liu, JY Kung… - The Journal of Clinical …, 2023 - Wiley Online Library
Studies have shown that angiotensin converting enzyme inhibitors (ACEIs) are superior in
primary and secondary prevention for cardiac mortality and morbidity to angiotensin receptor …

Angiotensin (1–7) delivered orally via probiotic in combination with exercise: Sex-dependent influence on health span

A Hernandez, Y Sun, A Banerjee… - The Journals of …, 2023 - academic.oup.com
Age-related declines in physical and cognitive function can have tremendous, negative
impacts on health span and quality of life. Therefore, we investigated the potential of utilizing …

Multiomics profiling of the impact of an angiotensin (1–7)-expressing probiotic combined with exercise training in aged male rats

LC Baptista, EL Zumbro, ZA Graham… - Journal of Applied …, 2023 - journals.physiology.org
Angiotensin (1–7)[Ang (1–7)] is an active heptapeptide of the noncanonical arm of the renin-
angiotensin system that modulates molecular signaling pathways associated with vascular …

Angiotensin Converting Enzyme Inhibitors Combined with Exercise for Hypertensive Seniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial

SA Harper, LC Baptista, LM Roberts, SJ Wherry… - Frontiers in …, 2020 - frontiersin.org
Prior evidence suggests that the choice of antihypertensive medication may influence
functional status among older adults with hypertension, particularly in conjunction with …

Azilsartan prevents muscle loss and fast-to slow-twitch muscle fiber shift in natural ageing sarcopenic rats

P Prajapati, A Kumar, S Mangrulkar… - Canadian Journal of …, 2023 - cdnsciencepub.com
Sarcopenia is a musculoskeletal disease that reduces muscle mass and strength in older
individuals. The study investigates the effects of azilsartan (AZL) on skeletal muscle loss in …

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

ML Erickson, JM Allen, DP Beavers, LM Collins… - GeroScience, 2023 - Springer
Exercise is a cornerstone of preventive medicine and a promising strategy to intervene on
the biology of aging. Variation in the response to exercise is a widely accepted concept that …