The functions of CAP superfamily proteins in mammalian fertility and disease

AS Gaikwad, J Hu, DG Chapple… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Members of the cysteine-rich secretory proteins (CRISPS), antigen 5 (Ag5)
and pathogenesis-related 1 (Pr-1)(CAP) superfamily of proteins are found across the …

CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization

JI Ernesto, M Weigel Muñoz, MA Battistone… - Journal of Cell …, 2015 - rupress.org
Ca2+-dependent mechanisms are critical for successful completion of fertilization. Here, we
demonstrate that CRISP1, a sperm protein involved in mammalian fertilization, is also …

Bitter taste receptors in the reproductive system: Function and therapeutic implications

P Lu, TA Moore Simas, E Delpapa… - Journal of Cellular …, 2024 - Wiley Online Library
Type 2 taste receptors (TAS2Rs), traditionally known for their role in bitter taste perception,
are present in diverse reproductive tissues of both sexes. This review explores our current …

Tracing the evolutionary history of the CAP superfamily of proteins using amino acid sequence homology and conservation of splice sites

A Abraham, DE Chandler - Journal of molecular evolution, 2017 - Springer
Proteins of the CAP superfamily play numerous roles in reproduction, innate immune
responses, cancer biology, and venom toxicology. Here we document the breadth of the …

[HTML][HTML] Sperm Migration and Hyaluronic Acid Binding: Implications for Male Fertility Evaluation

K Marchlewska, M Erkiert-Kusiak… - International Journal of …, 2024 - mdpi.com
Mature, vital, and motile spermatozoa are essential for reaching the oocyte and binding to
hyaluronic acid (HA) in the cumulus oophorus matrix. This study aims to determine the …

Does the pre-ovulatory pig oviduct rule sperm capacitation in vivo mediating transcriptomics of Catsper channels?

CA Martinez, M Alvarez-Rodriguez, D Wright… - International Journal of …, 2020 - mdpi.com
Spermatozoa need to conduct a series of biochemical changes termed capacitation in order
to fertilize. In vivo, capacitation is sequentially achieved during sperm transport and …

The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain

S Cottier, R Darwiche, F Meyenhofer… - Biology …, 2020 - journals.biologists.com
Members of the CAP/SCP/TAPS superfamily have been implicated in many different
physiological processes, including pathogen defense, sperm maturation and fertilization …

Protein tyrosine kinase signaling in the mouse oocyte cortex during sperm–egg interactions and anaphase resumption

LK McGinnis, J Luo, WH Kinsey - Molecular reproduction and …, 2013 - Wiley Online Library
Fertilization triggers activation of a series of pre‐programmed signal transduction pathways
in the oocyte that establish a block to polyspermy, induce meiotic resumption, and initiate …

15 Reptile Rich Secretory Venom Proteins Cysteine

ME Peichoto, ML Santoro - Handbook of Venoms and Toxins of …, 2021 - books.google.com
Cysteine-Rich Secretory Proteins (CRiSPs) are single-chain proteins with molecular masses
ranging from 20 to 30 kDa and 16 absolutely conserved cysteine residues. Most reptile …

Reptile venom cysteine-rich secretory proteins

ME Peichoto, ML Santoro - Handbook of Venoms and Toxins of …, 2021 - taylorfrancis.com
Cysteine-Rich Secretory Proteins (CRiSPs) are single-chain proteins with molecular masses
ranging from 20 to 30 kDa and 16 absolutely conserved cysteine residues. Most reptile …