For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …

Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to
display a variety of biological activities. Thiazole and its derivatives have attracted …

Abstract TMEM16A (ANO1) is a calcium-activated chloride channel (CaCC) expressed in
secretory epithelia, smooth muscle, and other tissues. Cell-based functional screening of∼ …

The main goal of the authors is to present an overview of adenosine and its receptors, which
are G-protein coupled receptors. The four known adenosine receptor subtypes are …

Adenosine is a purine nucleoside, responsible for the regulation of a wide range of
physiological and pathophysiological conditions by binding with four G-protein-coupled …

Blockade of A2A adenosine receptors (A2AARs) and inhibition of monoamine oxidase B
(MAO-B) in the brain are considered attractive strategies for the treatment of …

Adenosine, the purine nucleoside, mediates its effects through activation of four G-protein
coupled adenosine receptors (ARs) named as A 1, A 2A, A 2B and A 3. In particular, A 1 ARs …

Abstract A novel series of 5-((5-substituted-1H-1, 2, 4-triazol-3-yl) methyl)-4, 5, 6, 7-
tetrahydrothieno [3, 2-c] pyridines 5 (a–i) has been synthesized from thienopyridine …

2-(Acyl) amino-4 H-3, 1-benzothiazin-4-ones and related thienothiazinones were identified
as structurally novel antagonists at adenosine receptors (ARs). 6-Methyl-2-benzoylamino-4 …