CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin,
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
Amygdala pain mechanisms
V Neugebauer - Pain control, 2015 - Springer
A limbic brain area, the amygdala plays a key role in emotional responses and affective
states and disorders such as learned fear, anxiety, and depression. The amygdala has also …
states and disorders such as learned fear, anxiety, and depression. The amygdala has also …
Amylin: pharmacology, physiology, and clinical potential
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …
systems. Here, we review the literature in rodents and in humans on amylin research since …
Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes
Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …
Novel receptor partners and function of receptor activity-modifying proteins
A Christopoulos, G Christopoulos, M Morfis… - Journal of Biological …, 2003 - ASBMB
The receptor activity-modifying proteins (RAMPs) comprise a family of three accessory
proteins that heterodimerize with the calcitonin receptor-like receptor (CL receptor) or with …
proteins that heterodimerize with the calcitonin receptor-like receptor (CL receptor) or with …
The role of peptides in central sensitization
VS Seybold - Sensory Nerves, 2009 - Springer
Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …
Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier
Background The presence of calcitonin gene-related peptide and its receptors in multiple
brain areas and peripheral tissues previously implicated in migraine initiation and its many …
brain areas and peripheral tissues previously implicated in migraine initiation and its many …
GPCR modulation by RAMPs
Our conceptual understanding of the molecular architecture of G-protein coupled receptors
(GPCRs) has transformed over the last decade. Once considered as largely independent …
(GPCRs) has transformed over the last decade. Once considered as largely independent …
Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level
S Eftekhari, L Edvinsson - BMC neuroscience, 2011 - Springer
Background Calcitonin gene-related peptide (CGRP) has a key role in migraine
pathophysiology and is associated with activation of the trigeminovascular system. The …
pathophysiology and is associated with activation of the trigeminovascular system. The …