Efflux in Gram-negative bacteria: what are the latest opportunities for drug discovery?

T Gil-Gil, P Laborda, LE Ochoa-Sánchez… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

C Verdial, I Serrano, L Tavares, S Gil, M Oliveira - Biomedicines, 2023 - mdpi.com
Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple
hospital-and community-acquired infections, both in human and veterinary medicine. P …

Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance

P Laborda, S Lolle, S Hernando-Amado… - Nature …, 2024 - nature.com
Mutations in mexZ, encoding a negative regulator of the expression of the mexXY efflux
pump genes, are frequently acquired by Pseudomonas aeruginosa at early stages of lung …

The inactivation of the putative two-component system sensor PA14_27940 increases the susceptibility to several antibiotics and reduces the motility of Pseudomonas …

R Genova, T Gil-Gil, T Cuesta, JL Martínez… - International Journal of …, 2023 - mdpi.com
The identification of targets whose inactivation increases the activity of antibiotics helps to
fight antibiotic resistance. Previous work showed that a transposon-insertion mutant in the …

Antibiotic-Resistant Bacteria in Environmental Water Sources from Southern Chile: A Potential Threat to Human Health

M Jofré Bartholin, B Barrera Vega… - Microbiology …, 2023 - mdpi.com
Antimicrobial resistance (AMR) is a critical global issue affecting public and animal health.
The overuse of antibiotics in human health, animal production, agriculture, and aquaculture …

Use of adjuvants to improve antibiotic efficacy and reduce the burden of antimicrobial resistance

T Gil-Gil, P Laborda, JL Martínez… - Expert review of anti …, 2025 - Taylor & Francis
Introduction The increase of antibiotic resistance, together with the absence of novel
antibiotics, makes mandatory the introduction of novel strategies to optimize the use of …

Auxin-mediated regulation of susceptibility to toxic metabolites, c-di-GMP levels, and phage infection in the rhizobacterium Serratia plymuthica

M Rico-Jiménez, Z Udaondo, T Krell, MA Matilla - Msystems, 2024 - Am Soc Microbiol
The communication between plants and their microbiota is highly dynamic and involves a
complex network of signal molecules. Among them, the auxin indole-3-acetic acid (IAA) is a …

[HTML][HTML] Cefuroxime

AE Omole, AO Awosika, P Patel - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
Cefuroxime belongs to the second generation of cephalosporin antibiotics and is classified
as a β-lactam agent. Cefuroxime was approved by the US Food and Drug Administration …

Effect of Lactiplantibacillus plantarum cell-free culture on bacterial pathogens isolated from cystic fibrosis patients: in vitro and in vivo studies

CL Abán, S Orosco, JN Argañaraz Aybar… - Frontiers in …, 2024 - frontiersin.org
This study aimed to investigate the effects of the cell-free supernatant of Lactiplantibacillus
plantarum ATCC® 10241TM on the biofilm-forming capacity of Pseudomonas aeruginosa …

Assessing the feasibility of adjusting the dry matter content utilizing corn grits and cottonseed meal and inoculating with Lactiplantibacillus plantarum in the production …

Y Tang, F Yang, H Pang, S Zhao, H Ma, H Li… - Process Safety and …, 2024 - Elsevier
The feasibility of converting kitchen waste into fermented feed was investigated by adjusting
the dry matter (DM) content through addition of corn grits or cottonseed meal, in conjunction …