[HTML][HTML] Biochemistry of the hypoxia-inducible factor hydroxylases
G Fiorini, CJ Schofield - Current Opinion in Chemical Biology, 2024 - Elsevier
The hypoxia-inducible factors are α, β-heterodimeric transcription factors that mediate the
chronic response to hypoxia in humans and other animals. Protein hydroxylases belonging …
chronic response to hypoxia in humans and other animals. Protein hydroxylases belonging …
Targeting hypoxia-inducible Factor-1 (HIF-1) in Cancer: emerging therapeutic strategies and pathway regulation
Hypoxia-inducible factor-1 (HIF-1) is a key regulator for balancing oxygen in the cells. It is a
transcription factor that regulates the expression of target genes involved in oxygen …
transcription factor that regulates the expression of target genes involved in oxygen …
Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans.
When sufficient O2 is present, Fe (II)/2-oxoglutarate (2OG)-dependent oxygenases (human …
When sufficient O2 is present, Fe (II)/2-oxoglutarate (2OG)-dependent oxygenases (human …
Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome
Pacak-Zhuang syndrome is caused by mutations in the EPAS1 gene, which encodes for one
of the three hypoxia-inducible factor alpha (HIFα) paralogs HIF2α and is associated with …
of the three hypoxia-inducible factor alpha (HIFα) paralogs HIF2α and is associated with …
Utility of next-generation sequencing in identifying congenital erythrocytosis in patients with idiopathic erythrocytosis
S Anžej Doma, N Kraljić, A Kristan, N Debeljak… - Frontiers in …, 2024 - frontiersin.org
Background Congenital erythrocytosis (CE) is increasingly recognized as the cause of
erythrocytosis in patients in whom polycythemia vera and secondary acquired causes have …
erythrocytosis in patients in whom polycythemia vera and secondary acquired causes have …
Biophysical Characterization of Prolyl Hydroxylation-dependent HIF-1α Degradation
W He - 2024 - search.proquest.com
Metazoan life is dependent upon the utilization of O 2 for proper cellular metabolism and
energy production. Low levels of oxygen, or hypoxia, at the tissue level can occur due to …
energy production. Low levels of oxygen, or hypoxia, at the tissue level can occur due to …