Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits
treatment effectiveness and cure rate of diseases. Protein post-translational modifications …

Abstract The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide
molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal …

E3 ubiquitin ligases play an essential role in protein ubiquitination, which is involved in the
regulation of protein degradation, protein-protein interactions and signal transduction …

In the field of drug discovery, understanding how small molecule drugs interact with cellular
components is crucial. Our study introduces a novel methodology to uncover primary drug …

TGF-β signaling pathway has been demonstrated to be closely related to chemoresistance,
which is the major cause of recurrence and poor outcome in colorectal cancer (CRC) …

Since the discovery of copper induces cell death (cuprotosis) in 2022, it has been one of the
biggest research hotspots. cuprotosis related genes (CRGs) has been demonstrated to be a …

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), also known as type II
enteropathy-associated T-cell lymphoma, is a rare malignant lymphoma of the extranodal …

In this issue of Blood, Zhou et al reveal the role of KLHL6 inactivation in chemoresistance in
diffuse large B-cell lymphoma (DLBCL). 1 KLH6 is a cullinring ubiquitin type 3 ligase and a …

The current status and future trends of BTK inhibitor for diffuse large B cell lymphoma The
current status and future trends of BTK inhibitor for diffuse large B cell lymphoma Pharmacol …