Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research
Background The role of the human microbiome in health and disease is an emerging and
important area of research; however, there is a concern that African populations are under …
important area of research; however, there is a concern that African populations are under …
Metagenomic sequencing to detect respiratory viruses in persons under investigation for COVID-19
A Babiker, HL Bradley, VD Stittleburg… - Journal of clinical …, 2020 - Am Soc Microbiol
Broad testing for respiratory viruses among persons under investigation (PUIs) for SARS-
CoV-2 has been performed inconsistently, limiting our understanding of alternative viral …
CoV-2 has been performed inconsistently, limiting our understanding of alternative viral …
Quasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis
New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission
ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation …
ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation …
[HTML][HTML] Dynamics of HIV-1 quasispecies diversity of participants on long-term antiretroviral therapy based on intrahost single-nucleotide variations
Y Zhang, Q Yin, M Ni, T Liu, C Wang, C Song… - International Journal of …, 2021 - Elsevier
Objectives Human immunodeficiency virus (HIV) quasispecies diversity presents a large
barrier to the eradication of HIV. The aim of this study was to investigate intrahost HIV …
barrier to the eradication of HIV. The aim of this study was to investigate intrahost HIV …
HIV-1 phylogenetics and vaccines
M Rolland - Current Opinion in HIV and AIDS, 2019 - journals.lww.com
Compared with how widely HIV-1 diversity is recognized as a critical issue for vaccine
research, relatively few genetically informed vaccine solutions have been compared, in part …
research, relatively few genetically informed vaccine solutions have been compared, in part …
HIV broadly neutralizing antibody escapability drives the therapeutic efficacy of vectored immunotherapy
Broadly neutralizing antibodies (bNAbs) have shown great promise for prevention and
treatment of HIV infection. Breadth of bNAb neutralization, measured in vitro across panels …
treatment of HIV infection. Breadth of bNAb neutralization, measured in vitro across panels …
Clinical metagenomics for infection diagnosis
S Robert, L Filkins - Genomic and Precision Medicine, 2019 - Elsevier
Clinical metagenomics enables universal pathogen detection by unbiased next-generation
sequencing. Recent advances in sequencing and bioinformatics technology have paved the …
sequencing. Recent advances in sequencing and bioinformatics technology have paved the …
Novel diagnostics techniques for detection of Coronavirus disease 2019
G Tripathi, MB Tripathi - Evolving Landscape of Molecular Diagnostics, 2024 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the rapid spread
of the severe acute respiratory syndrome coronavirus-2 virus, has posed an unprecedented …
of the severe acute respiratory syndrome coronavirus-2 virus, has posed an unprecedented …
[图书][B] Modeling the HIV Genetic Bottleneck in vitro
TA Caldwell III - 2023 - search.proquest.com
As of the year 2023, there has yet to be developed an effective prophylactic vaccine against
HIV-1 infection. One likely reason for prior failures in vaccine trials is that vaccines have …
HIV-1 infection. One likely reason for prior failures in vaccine trials is that vaccines have …