Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …

Ovarian cancer is one of the most common gynecological malignancies. Upon initial
diagnosis, the majority of patients present with widespread metastatic growth within the …

Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …

Despite decades of search for anticancer drugs targeting solid tumors, this group of
diseases remains largely incurable, especially if in advanced, metastatic stage. In this …

Background Systemic cancer spread is preceded by the establishment of a permissive
microenvironment in the target tissue of metastasis-the premetastatic niche. As crucial …

Metastasis is a complex process, which depends on the interaction between tumor cells and
host organs. Driven by the primary tumor, the host organ will establish an environment …

The emergence of disseminated metastasis is the leading cause of mortality in patients with
malignant tumor. The pre-metastatic microenvironment, including the primary tumor-derived …

Experimental and clinical studies indicate that cells of the innate and adaptive immune
system have both anti‐and pro‐tumor activities. This dual role of the immune system has led …