Targeting RNA structures with small molecules

JL Childs-Disney, X Yang, QMR Gibaut… - Nature Reviews Drug …, 2022 - nature.com
RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

RNA structural dynamics as captured by molecular simulations: a comprehensive overview

J Sponer, G Bussi, M Krepl, P Banáš, S Bottaro… - Chemical …, 2018 - ACS Publications
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

ViennaRNA Package 2.0

R Lorenz, SH Bernhart… - Algorithms for molecular …, 2011 - Springer
Background Secondary structure forms an important intermediate level of description of
nucleic acids that encapsulates the dominating part of the folding energy, is often well …

Dynamic DNA nanotechnology: toward functional nanoscale devices

M DeLuca, Z Shi, CE Castro, G Arya - Nanoscale Horizons, 2020 - pubs.rsc.org
Dynamic DNA nanotechnology involves the creation of nanoscale devices made of DNA
whose primary function arises from their ability to undergo controlled motion or …

Mfold web server for nucleic acid folding and hybridization prediction

M Zuker - Nucleic acids research, 2003 - academic.oup.com
The abbreviated name,'mfold web server', describes a number of closely related software
applications available on the World Wide Web (WWW) for the prediction of the secondary …

Rational design of dna hydrogels based on molecular dynamics of polymers

Y Li, R Chen, B Zhou, Y Dong, D Liu - Advanced Materials, 2024 - Wiley Online Library
In recent years, DNA has emerged as a fascinating building material to engineer hydrogel
due to its excellent programmability, which has gained considerable attention in biomedical …

Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

M Zuker, P Stiegler - Nucleic acids research, 1981 - academic.oup.com
This paper presents a new computer method for folding an RNA molecule that finds a
conformation of minimum free energy using published values of stacking and destabilizing …

Predicting DNA duplex stability from the base sequence.

KJ Breslauer, R Frank, H Blöcker… - Proceedings of the …, 1986 - National Acad Sciences
We report the complete thermodynamic library of all 10 Watson-Crick DNA nearest-neighbor
interactions. We obtained the relevant thermodynamic data from calorimetric studies on 19 …

The equilibrium partition function and base pair binding probabilities for RNA secondary structure

JS McCaskill - Biopolymers: Original Research on …, 1990 - Wiley Online Library
A novel application of dynamic programming to the folding problem for RNA enables one to
calculate the full equilibrium partition function for secondary structure and the probabilities of …

The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites

J Shine, L Dalgarno - … of the National Academy of Sciences, 1974 - National Acad Sciences
With a stepwise degradation and terminal labeling procedure the 3′-terminal sequence of
E. coli 16S ribosomal RNA is shown to be Pyd-ACCUCCUU-AOH. It is suggested that this …