Synthetic genetic oscillators demonstrate the functional importance of phenotypic variation in pneumococcal-host interactions
AS Rueff, R Van Raaphorst, SD Aggarwal… - Nature …, 2023 - nature.com
Phenotypic variation is the phenomenon in which clonal cells display different traits even
under identical environmental conditions. This plasticity is thought to be important for …
under identical environmental conditions. This plasticity is thought to be important for …
CRISPR Tools for Engineering Prokaryotic Systems: Recent Advances and New Applications
In the past decades, the broad selection of CRISPR-Cas systems has revolutionized
biotechnology by enabling multimodal genetic manipulation in diverse organisms. Rooted in …
biotechnology by enabling multimodal genetic manipulation in diverse organisms. Rooted in …
Design and Model-Driven Analysis of Synthetic Circuits with the Staphylococcus aureus Dead-Cas9 (sadCas9) as a Programmable Transcriptional Regulator in …
D De Marchi, R Shaposhnikov, S Gobaa… - ACS Synthetic …, 2024 - ACS Publications
Synthetic circuit design is crucial for engineering microbes that process environmental cues
and provide biologically relevant outputs. To reliably scale-up circuit complexity, the …
and provide biologically relevant outputs. To reliably scale-up circuit complexity, the …
Harnessing CRISPR interference to re-sensitize laboratory strains and clinical isolates to last resort antibiotics
A Frusteri Chiacchiera, M Casanova, M Bellato… - bioRxiv, 2024 - biorxiv.org
The global race against antimicrobial resistance requires novel antimicrobials that are not
only effective in killing specific bacteria, but also minimize the emergence of new …
only effective in killing specific bacteria, but also minimize the emergence of new …
[HTML][HTML] Rewiring capsule production by CRISPRi-based genetic oscillators demonstrates a functional role of phenotypic variation in pneumococcal-host interactions
AS Rueff, R van Raaphorst, S Aggarwal… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Phenotypic variation is the phenomenon in which clonal cells display different traits even
under identical environmental conditions. This plasticity is thought to be important for …
under identical environmental conditions. This plasticity is thought to be important for …
Engineering CRISPR-Based Toggle Switches in Escherichia coli
Y Xu - 2023 - search.proquest.com
In the field of synthetic biology, genetic engineering techniques are used to create modular
components and novel biological interactions within microorganisms. One example of this is …
components and novel biological interactions within microorganisms. One example of this is …
Combining positive and negative regulation for modular and robust biomolecular control architectures
Engineered biotechnologies are powered by synthetic gene regulation and control systems,
known as genetic circuits, which must be modular and robust to disturbances if they are to …
known as genetic circuits, which must be modular and robust to disturbances if they are to …
Progettazione e caratterizzazione di circuiti sintetici basati su tecnologia CRISPRi per inibire i geni di resistenza antibiotica nei batteri.
A FRUSTERI CHIACCHIERA - 2022 - iris.unipv.it
Bacterial evolution is driven by rapid adaptation to changing environments where adverse
conditions must be faced. The horizontal exchange of genetic information, along with the …
conditions must be faced. The horizontal exchange of genetic information, along with the …