This article critically examines the use of factorial and response surface methodology in
modern experimental design and optimization. A survey of important screening and …

Since its inception, the dissolution test has come under increasing levels of scrutiny
regarding its relevance, especially to the correlation of results to levels of drug in blood. The …

The aim of the present work was to develop a new multiparticulate system, designed for
colon-specific delivery of celecoxib for both systemic (in chronotherapic treatment of arthritis) …

Background Fixed dose combination (FDC) products are common in the treatment of various
disease such as hypertension, diabetes, HIV and HCV, Pain, Respiratory disease for …

A niosomal formulation, functionalized with N-palmitoylglucosamine, was developed as
potential brain targeted delivery system of dynorphin-B. In fact, this endogenous …

Development of modified-release oral tablets of drug products usually requires release-
modifying polymers at the level of above 50% of the total weight. This makes the …

The present investigation concerns with the development and optimization of an in situ
forming formulation using 3 3 full factorial design experimentation. Metformin, an antidiabetic …

The aim of this study was to apply quality by design (QbD) for pharmaceutical development
of felodipine solid mixture (FSM) containing hydrophilic carriers and/or polymeric …

A variety of factors were systemically evaluated in order to establish the characteristics of the
niosomes obtained with a high-pressure homogenizer. The vesicular sizing parameters …

The present work explores the application of melt granulation technology to develop a high
drug loaded sustained release matrix tablet of Metformin HCl using hydroxypropylcellulose …