Mesenchymal stem cells (MSCs) display substantial cell-to-cell variation. This heterogeneity
manifests among donors, among tissue sources, and within cell populations. Such pervasive …

Given the observed efficacy of culture‐expanded multipotential stromal cells, also termed
mesenchymal stem cells (MSCs), in the treatment of graft‐versus host and cardiac disease, it …

Immune reactions play important roles in determining the in vivo fate of bone substitute
materials, either in new bone formation or inflammatory fibrous tissue encapsulation. The …

Background Articular cartilage displays a poor repair capacity. The aim of cell-based
therapies for cartilage defects is to repair damaged joint surfaces with a functional …

In regenerative medicine, bone marrow is a promising source of mesenchymal stem cells
(MSCs) for a broad range of cellular therapies. This research addresses a basic prerequisite …

The osteoimmunomodulatory property of bone biomaterials is a vital property determining
the in vivo fate of the implants. Endowing bone biomaterials with favorable …

Biomaterial implantation triggers inflammatory reactions. Understanding the effect of
physicochemical features of biomaterials on the release of inflammatory cytokines from …

Mesenchymal stem cells (MSCs) have to be culture expanded to gain relevant cell numbers
for therapeutic applications. However, within 2–3 months the proliferation rate of MSCs …

The enhancement of bone regeneration with biological agents including osteogenic growth
factors and mesenchymal stem cells (MSCs) is becoming a clinical reality. Many exciting …

Objective To test the hypothesis that CD45lowCD271+ bone marrow multipotential stromal
cells (MSCs) are abundant in the trabecular bone niche and to explore their functional …