Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy
Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
Recent advances in hepatitis B treatment
GM Prifti, D Moianos, E Giannakopoulou, V Pardali… - Pharmaceuticals, 2021 - mdpi.com
Hepatitis B virus infection affects over 250 million chronic carriers, causing more than
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …
Pregenomic RNA Launch Hepatitis B virus replication system facilitates the mechanistic study of antiviral agents and drug-resistant variants on covalently closed …
Hepatitis B virus (HBV) replicates its genomic DNA by reverse transcription of an RNA
intermediate, termed pregenomic RNA (pgRNA), within nucleocapsid. It had been shown …
intermediate, termed pregenomic RNA (pgRNA), within nucleocapsid. It had been shown …
Expression of functional molecule on plasmacytoid dendritic cells is associated with HBsAg loss in HBeAg-positive patients during PEG-IFN α-2a treatment
W Cao, S Xie, L Zhang, X Bi, Y Lin, L Yang… - Frontiers in …, 2022 - frontiersin.org
Objective The ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to
clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the …
clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the …
[HTML][HTML] Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach
P Singh, D Kairuz, P Arbuthnot… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Global prophylactic vaccination programmes have helped to curb new hepatitis B virus
(HBV) infections. However, it is estimated that nearly 300 million people are chronically …
(HBV) infections. However, it is estimated that nearly 300 million people are chronically …
Heat shock protein family a member 1 promotes intracellular amplification of hepatitis B virus covalently closed circular DNA
Hepatitis B virus (HBV) contains a partially double-stranded relaxed circular DNA (rcDNA)
genome that is converted into a covalently closed circular DNA (cccDNA) in the nucleus of …
genome that is converted into a covalently closed circular DNA (cccDNA) in the nucleus of …
Fast differentiation of HepaRG cells allowing hepatitis B and delta virus infections
J Lucifora, M Michelet, A Salvetti, D Durantel - Cells, 2020 - mdpi.com
HepaRG cells are liver bipotent progenitors acquiring hepatocytes features when
differentiated in the presence of dimethylsulfoxide (DMSO). Differentiated HepaRG …
differentiated in the presence of dimethylsulfoxide (DMSO). Differentiated HepaRG …
Hepatitis B virus: promising drug targets and therapeutic implications
Introduction: Current therapy for infection with hepatitis B virus (HBV) rarely clears the virus,
and viremia commonly resurges following treatment withdrawal. To prevent serious …
and viremia commonly resurges following treatment withdrawal. To prevent serious …
Triple motif proteins 19 and 38 correlated with treatment responses and HBsAg clearance in HBeAg-negative chronic hepatitis B patients during peg-IFN-α therapy
H Luo, G Tan, X Hu, Y Li, D Lei, Y Zeng, B Qin - Virology Journal, 2023 - Springer
Objective To investigate whether the expression of triple motif protein 19/38 (TRIM19/38)
mRNA in peripheral blood mononuclear cells (PBMCs) of HBeAg-negative chronic hepatitis …
mRNA in peripheral blood mononuclear cells (PBMCs) of HBeAg-negative chronic hepatitis …