Depression pathophysiology: Astrocyte mitochondrial melatonergic pathway as crucial hub

G Anderson - International Journal of Molecular Sciences, 2022 - mdpi.com
Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …

The emerging role of long noncoding RNA in depression and its implications in diagnostics and therapeutic responses

XL Zhong, Y Du, L Chen, Y Cheng - Journal of Psychiatric Research, 2023 - Elsevier
Depression is one of the most common mental illnesses, affecting more than 350 million
people worldwide. However, the occurrence of depression is a complex process involving …

[HTML][HTML] Integrative bioinformatics and artificial intelligence analyses of transcriptomics data identified genes associated with major depressive disorders including …

A Bouzid, A Almidani, M Zubrikhina, A Kamzanova… - Neurobiology of …, 2023 - Elsevier
Major depressive disorder (MDD) is a common mental disorder and is amongst the most
prevalent psychiatric disorders. MDD remains challenging to diagnose and predict its onset …

[HTML][HTML] Analysis of genetic diversity in patients with major psychiatric disorders versus healthy controls: A molecular-genetic study of 1698 subjects genotyped for 100 …

HH Stassen, S Bachmann, R Bridler, K Cattapan… - Psychiatry …, 2024 - Elsevier
Background This study analyzed the extent to which irregularities in genetic diversity
separate psychiatric patients from healthy controls. Methods Genetic diversity was quantified …

Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice

Y Qin, XY Zhang, Y Liu, Z Ma, S Tao, Y Li… - Translational …, 2023 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core
symptoms that consist of social deficits and repetitive behaviors. Unfortunately, no effective …

Down-regulated miR-16-2 in peripheral blood is positively correlated with decreased bilateral insula volume in patients with major depressive disorder

Y Wang, Y Yan, J Wei, X Yang, M Wang, L Zhao… - Journal of Affective …, 2023 - Elsevier
Abstract Background The downregulated microRNA-16-2-3p (miR-16-2) had been believed
to be associated with major depressive disorder (MDD). This study aimed to investigate the …

[HTML][HTML] Dysconnectivity of the brain functional network and abnormally expressed peripheral transcriptional profiles in patients with anxious depression

J Wei, M Wang, Y Dou, Y Wang, Y Du, L Zhao… - Journal of psychiatric …, 2024 - Elsevier
Background Major depressive disorder (MDD) is a heterogeneous mental disorder, and
accompanying anxiety symptoms, known as anxious depression (AD), are the most common …

[HTML][HTML] MicroRNAs as potential biomarkers for diagnosis of major depressive disorder and influence of antidepressant treatment

B Martinez, PV Peplow - NeuroMarkers, 2024 - Elsevier
We performed a PubMed search for microRNA biomarkers in major depressive disorder
(MDD) and found 25 original research articles on studies performed with human patients …

Potential Shared Mitochondrial-Related Gene Signatures and Molecular Mechanisms Between Polycystic Ovary Syndrome (PCOS) and Major Depressive Disorder …

H Liang, Y Liu, C Zhang, Y Qin - Molecular Biotechnology, 2024 - Springer
Polycystic ovary syndrome (PCOS) is strongly associated with major depressive disorder
(MDD), but the shared pathophysiological mechanisms between them are ambiguous, and …

[HTML][HTML] Misdiagnoses of psychiatric disorders and the utility of diagnostic microRNA biomarkers

B Martinez, PV Peplow - NeuroMarkers, 2024 - Elsevier
Due to overlapping symptoms and similarities with other illnesses, misdiagnosis and
inappropriate treatment of psychiatric disorders frequently occur. Objective laboratory-based …