The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …

The skin is a barrier site that is exposed to a wide variety of potential pathogens. As in other
organs, pathogens that invade the skin are recognized by pattern-recognition receptors …

The serum complement system, which represents a chief component of innate immunity, not
only participates in inflammation but also acts to enhance the adaptive immune response …

Contact allergies are complex diseases, and one of the important challenges for public
health and immunology. The German 'Federal Institute for Risk Assessment'hosted an …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation
of immune responses associated with a broad range of diseases, including autoimmunity …

Natural antibodies are produced at tightly regulated levels in the complete absence of
external antigenic stimulation. They provide immediate, early and broad protection against …

VOL. 102 NO. 5S I NOVEMBER 2018 7 WWW. MDEDGE. COM/CUTIS region. Current
research on the pathogenesis of psoriasis examines the complex interactions among …