Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint
inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor …

Blockade of the programmed cell death-1 (PD-1) axis has already been established as an
effective treatment of non-small cell lung cancer. Immunohistochemistry (IHC) for …

Immune checkpoint blockade (ICB) therapy has achieved breakthroughs in the treatment of
advanced non–small cell lung cancer (NSCLC). Nevertheless, the low response due to …

Generating realistic virtual patients from a limited amount of patient data is one of the major
challenges for quantitative systems pharmacology modeling in immuno-oncology …

Myeloid-derived suppressor cells (MDSCs) have been demonstrated to suppress antitumor
immunity and induce resistance to PD-1/PD-L1 blockade immunotherapy in gastric and …

Simple Summary The present review was performed in order to provide a comprehensive
overview of the existing literature concerning the applications of positron emission …

Purpose This study aimed to investigate the value of 18F-fluorodeoxyglucose positron
emission tomography/computed tomography (18F-FDG PET/CT) in predicting early …

The best current biomarker strategies for predicting response to immune checkpoint inhibitor
(ICI) therapy fail to account for interpatient variability in response rates. The histologic tumor …

High expression of PD-L1 predicts PD-1/PD-L1 inhibitor benefit, meanwhile a few PD-L1-
negative patients still benefit from these drugs. In this study, we aimed to explore the …

Background Emerging evidence indicates that immunogenicity plays an important role in
intrahepatic cholangiocarcinoma (ICC). Herein, we systematically evaluated the clinical …