Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Binding and spectroscopic parameters for a series of mixed-ligand complexes on binding to
DNA have been determined. The application of mixed-ligand complexes permits the …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

We have determined the domains of the mammalian high mobility group (HMG) I
chromosomal proteins necessary and sufficient for binding to the narrow minor groove of …

Of this large and diverse category of human afflictions we have already touched upon
genetic disorders in Section 1.3. 3 [link] above. Other major types of non-communicable …

DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

An X-ray crystallographic structure analysis has been carried out on the complex between
the antibiotic and DNA fluorochrome Hoechst 33258 and a synthetic B-DNA dodecamer of …

The chemical methylating agents methylmethane sulfonate (MMS) and N-methyl-N '-nitro-N-
nitrosoguanidine (MNNG) have been used for decades as classical DNA damaging agents …