Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel
strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an …

Photodynamic Therapy (PDT) holds a great promise for cancer patients, however, due to the
hypoxic characteristics of most solid tumors and the limited penetration depth of light in …

Despite the recent advances in cancer therapy, cancer chemoresistance looms large along
with radioresistance, a major challenge in dire need of thorough and minute investigation …

Growing evidence indicates that iron overload is an independent risk factor for osteoporosis.
However, the mechanisms are not fully understood. The purpose of our study was to …

Abstract Aims Lipocalin 2 (Lcn2) is an antioxidant-related protein upregulated in various
cellular stress conditions, especially cancer. In this study, we abrogated Lcn2 expression in …

Ferroptosis is a type of cell death driven by iron overload and lipid peroxidation. It is
considered a key mechanism in the development of various diseases such as …

The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and
poor prognosis, and the incidence and death rate is increasing yearly. Surgery is often used …

Significance: This study innovates by systematically integrating the molecular mechanisms
of iron death and its application in cancer therapy. By deeply analyzing the interaction …

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

The limitations of existing monotherapies underscore the necessity of exploring innovative
synergistic anticancer interventions. Ferroptosis, an iron-dependent form of cell death, is …