The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

It has been postulated that during human fetal development, all cells of the lung epithelium
derive from embryonic, endodermal, NK2 homeobox 1–expressing (NKX2-1+) precursor …

The liver is one of the largest organs in the body and is responsible for a diverse repertoire
of metabolic processes. Such processes include the secretion of serum proteins …

Hepatic metastases are amenable to ablation; however, many patients are not suitable
candidates for such therapy and recurrence is common. The tumor microenvironment is …

ONCR-177 is an engineered recombinant oncolytic herpes simplex virus (HSV) with
complementary safety mechanisms, including tissue-specific miRNA attenuation and mutant …

Orthotopic liver transplantation remains the only curative treatment for liver disease.
However, the number of patients who die while on the waiting list (15%) has increased in …

Direct‐acting antiviral agents (DAAs) are highly effective and well tolerated in patients with
chronic hepatitis C virus infection, including those with compensated cirrhosis. However …

Next generation sequencing has revealed the presence of numerous RNA viruses in animal
reservoir hosts, including many closely related to known human pathogens. Despite their …