Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet
medical need worldwide. The pathogenesis of AD involves various pathophysiological …

Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of
the disease and continual increase in patient numbers, developing effective therapies to …

Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central
nervous system (CNS) during the early stages of embryonic development. After colonizing …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

The proliferation and activation of microglial cells is a hallmark of several neurodegenerative
conditions. This mechanism is regulated by the activation of the colony-stimulating factor 1 …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the
developed countries. There is no effective treatment capable of slowing down disease …

Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …