Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Structural and functional complexities of the mammalian lung evolved to meet a unique set
of challenges, namely, the provision of efficient delivery of inspired air to all lung units within …

A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a
lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but …

Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

This review compares the manner in which physical stress imposed on the parenchyma,
vasculature and thorax and the thoraco-pulmonary interactions, drive both developmental …

Pulmonary and systemic insults from inhalation injury can complicate the care of burn
patients and contribute to significant morbidity and mortality. However, recent progress in …

Following right pneumonectomy (PNX), the remaining lung expands and its perfusion more
than doubles. Tissue and microvascular mechanical stresses are putative stimuli for …

Following right pneumonectomy (PNX), the remaining lung expands and its perfusion
doubles. Tissue and microvascular mechanical stresses are putative stimuli for initiating …

Major lung resection is a robust model that mimics the consequences of loss-of-functioning
lung units. We previously observed in adult canines, following 42% and 58% lung resection …

Physical forces critically shape thoraco-pulmonary development, growth, and adaptation. In
fetal-to-early postnatal life, the lung and thorax are highly sensitive to mechanical stimuli …