Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Survey on multi-omics, and multi-omics data analysis, integration and application

MH Shahrajabian, W Sun - Current Pharmaceutical Analysis, 2023 - benthamdirect.com
Multi-omics approaches have developed as a profitable technique for plant systems, a
popular method in medical and biological sciences underlining the necessity to outline new …

[HTML][HTML] Identification of therapeutic targets for amyotrophic lateral sclerosis using PandaOmics–an AI-enabled biological target discovery platform

FW Pun, BHM Liu, X Long, HW Leung… - Frontiers in aging …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer's disease

HM Mansour, HM Fawzy, AS El-Khatib… - Neural regeneration …, 2022 - journals.lww.com
Numerous molecular mechanisms are being examined in an attempt to discover disease-
modifying drugs to slow down the underlying neurodegeneration in Alzheimer's disease …

From multi-omics approaches to precision medicine in amyotrophic lateral sclerosis

G Morello, S Salomone, V D'Agata… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

[HTML][HTML] Drug repurposing: a network-based approach to amyotrophic lateral sclerosis

G Fiscon, F Conte, S Amadio, C Volonté, P Paci - Neurotherapeutics, 2021 - Elsevier
The continuous adherence to the conventional “one target, one drug” paradigm has failed so
far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases …

Where and why modeling amyotrophic lateral sclerosis

F Liguori, S Amadio, C Volonté - International Journal of Molecular …, 2021 - mdpi.com
Over the years, researchers have leveraged a host of different in vivo models in order to
dissect amyotrophic lateral sclerosis (ALS), a neurodegenerative/neuroinflammatory …

Omics data and their integrative analysis to support stratified medicine in neurodegenerative diseases

V La Cognata, G Morello, S Cavallaro - International Journal of Molecular …, 2021 - mdpi.com
Molecular and clinical heterogeneity is increasingly recognized as a common characteristic
of neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease …

[HTML][HTML] Genomic and transcriptomic advances in amyotrophic lateral sclerosis

M Rizzuti, L Sali, V Melzi, S Scarcella… - Ageing Research …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and the most common
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …

What can machine learning approaches in genomics tell us about the molecular basis of amyotrophic lateral sclerosis?

C Vasilopoulou, AP Morris, G Giannakopoulos… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is the most common late-onset motor neuron disorder,
but our current knowledge of the molecular mechanisms and pathways underlying this …